Welcome to the BASICS Trial Website

The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.

 Background & Aim

Two new devices have been introduced to try to reduce shunt infection; antibiotic-impregnated (Bactiseal) and silver-impregnated   (Silverline) shunts. This study will compare these new shunts to standard shunts in a study called a randomised multi-centre controlled trial.

This will be a national trial recruiting 1600 participants from specialist neurosurgical units. Our goal is to establish which VPS provides most protection against infection and to ensure standardisation of care and infection

rates across the country.




Recruitment status

Site Recruitment
Alder Hey Children's Hospital 114
The Walton Centre 152
Southampton General Hospital 163
Leeds General Infirmary 77
Queens Medical Centre-Nottingham 133
Royal Manchester Children's Hospital 45
Great Ormond Street Hospital 72
Salford Royal Hospital 79
Addenbrookes Hospital 81
Sheffield Children's Hospital 43
Royal Hallamshire Hospital 22
University Hospital of Wales-Cardiff 121

Birmingham Children's Hospital
Bristol 179
Kings College Hospital 36
Royal Sick Children's Hospital-Edinburgh 8
Western General Hospital- Edinburgh 5
James Cook Hospital 22
Children's University Hospital Dublin 68
The National Hospital, Queens Square 68
The Royal Victoria Infirmary, Newcastle 14
Total recruitment 1532
Table last updated 16th June 2017  




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