Welcome to the BASICS Trial Website

The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.

 Background & Aim

Two new devices have been introduced to try to reduce shunt infection; antibiotic-impregnated (Bactiseal) and silver-impregnated   (Silverline) shunts. This study will compare these new shunts to standard shunts in a study called a randomised multi-centre controlled trial.

This will be a national trial recruiting 1600 participants from specialist neurosurgical units. Our goal is to establish which VPS provides most protection against infection and to ensure standardisation of care and infection

rates across the country.




Recruitment status

Site Recruitment
Alder Hey Children's Hospital 120
The Walton Centre 153
Southampton General Hospital 175
Leeds General Infirmary 88
Queens Medical Centre-Nottingham 138
Royal Manchester Children's Hospital 46
Great Ormond Street Hospital 74
Salford Royal Hospital 79
Addenbrookes Hospital 85
Sheffield Children's Hospital 43
Royal Hallamshire Hospital 22
University Hospital of Wales-Cardiff 126

Birmingham Children's Hospital
Bristol 187
Kings College Hospital 36
Royal Sick Children's Hospital-Edinburgh 8
Western General Hospital- Edinburgh 5
James Cook Hospital 22
Children's University Hospital Dublin 69
The National Hospital, Queens Square 73
The Royal Victoria Infirmary, Newcastle 14
Total recruitment 1594
Table last updated 16th June 2017  




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